Cellerant Therapeutics

	Cellerant Pipeline

	What Are Stem Cells?

	CLT-008 For Neutropenia

	CLT-008 For Nuclear Terror

	Cancer Stem Cell Antibodies

	CLT-001: Overview

	For Cancer

	For Sickle Cell Disease

What is High Dose Chemotherapy?

Chemotherapy drugs which are used to kill cancer cells also damage normal cells. One of the major organs affected by high doses of chemotherapy drugs is the bone marrow, where the blood-forming stem cells reside. In high-dose chemotherapy, the patient receives high doses of multiple chemotherapy drugs. The doses are so high that the patient's marrow is destroyed or significantly injured. In order to rescue the patient, a stem cell transplant is performed using stem cells taken from the patient before the chemotherapy procedure. This procedure has become increasingly common for cancers including non-Hodgkin’s lymphoma, multiple myeloma, and breast cancer.

Autologous Stem Cell Transplant and Purification

Stem cell rescue with the patient's own stem cells is a relatively safe way to rescue patients from the consequences of high dose chemotherapy, and it frees physicians to apply chemotherapy aggressively. However, relapse is still possible. We don't know whether relapse occurs because not all of the cancer was killed by the chemotherapy, or whether the unpurified stem cell transplant reintroduces cancer into the patient.

Most stem cell transplants are performed using graft material that is either completely unpurified or only semi-purified. Unpurified bone marrow or mobilized peripheral blood may contain contaminating tumor cells, especially in metastatic or aggressive disease. Studies have shown that relapse in patients with circulating tumor cells or bone marrow involvement is much higher after high dose chemotherapy followed by stem cell transplant than in other patients.

Cellerant's CLT-001 technology selects for a cell population which only contains hematopoietic stem and progenitor cells. Each cell in the final formulation is individually interrogated, unlike cell separation technologies which process cells in bulk. In addition, Cellerant's proprietary technology positively selects for stem cells, rather than trying to search for and eliminate tumor cells which vary too widely between patients and diseases.